Analytical methods for nano and biosciences

Research activity

Research activity focuses on separative techniques (SEC and the innovative field-flow fractionation techniques) and their hyphenation with uncorrelated techniques for particles analysis (e.g. laser scattering and spectroscopic techniques, and mass spectrometry) for size, functional and quantitative analysis of nano/bioparticles in environmental, clinical, industrial and forensic fields.

Scientific coordinator: Prof Pierluigi Reschiglian

ERC panels

PE4, Physical and Analytical Chemical sciences: analytical chemistry, chemical theory, physical chemistry/chemical physics
PE4_5 Analytical chemistry
PE4_9 Method development in chemistry

LS2_3 Proteomics
LS2_13 Systems biology
LS3_12 Stem cell biology
LS7_1 Medical engineering and technology
LS7_2 Diagnostic tools (e.g. genetic, imaging)
LS9_5 Food sciences (including food technology, nutrition)

Collaborations

Istituto Ortopedico Rizzoli Bologna Laboratorio Ramses Ramses

Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna

ISTEC-CNR Faenza (Istituto di Ricerche Tecnologiche per la Ceramica)

Ospedale Universitario di Modena e Reggio Emilia, Centro per la Diagnosi di Malattie Virali, Dipartimento di Medicina Sperimentale.

Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con interesse Trapiantologico, Oncologico e di Medicina Rigenerativa, UniMoRe

Istituto Oncologico Seragnoli, S.Orsola Bologna

Dipartimento di Genetica medica, Università di Ferrara

Most recent pubblications

• Widening the Therapeutic Perspectives of Clofazimine by Its Loading in Sulfobutylether β-Cyclodextrin Nanocarriers: Nanomolar IC50 Values against MDR S. epidermidis. Wankar J, Bonvicini F, Benkovics G, Marassi V, Malanga M, Fenyvesi E, Gentilomi GA, Reschiglian P, Roda B, Manet I. Mol Pharm. 2018 Sep 4;15(9):3823-3836.
• Flow field-flow fractionation and multi-angle light scattering as a powerful tool for the characterization and stability evaluation of drug-loaded metal-organic framework nanoparticles. Roda B, Marassi V, Zattoni A, Borghi F, Anand R, Agostoni V, Gref R, Reschiglian P, Monti S. Anal Bioanal Chem. 2018 Aug;410(21):5245-5253.
• Characterization of the Tissue and Stromal Cell Components of Micro-Superficial Enhanced Fluid Fat Injection (Micro-SEFFI) for Facial Aging Treatment. Rossi M, Roda B, Zia S, Vigliotta I, Zannini C, Alviano F, Bonsi L, Zattoni A, Reschiglian P, Gennai A. Aesthet Surg J. 2018
• A new analytical platform based on field-flow fractionation and olfactory sensor to improve the detection of viable and non-viable bacteria in food. Roda B, Mirasoli M, Zattoni A, Casale M, Oliveri P, Bigi A, Reschiglian P, Simoni P, Roda A. Anal Bioanal Chem. 2016.
• Role of Carbonyl Modifications on Aging-Associated Protein Aggregation. Tanase M, Urbanska AM, Zolla V, Clement CC, Huang L, Morozova K, Follo C, Goldberg M, Roda B, Reschiglian P, Santambrogio L. Sci Rep. 2016 Jan 18;6:1931.
• Hollow-fiber flow field-flow fractionation and multi-angle light scattering investigation of the size, shape and metal-release of silver nanoparticles in aqueous medium for nano-risk assessment. Marassi V, Casolari S, Roda B, Zattoni A, Reschiglian P, Panzavolta S, Tofail SA, Ortelli S, Delpivo C, Blosi M, Costa AL. J Pharm Biomed Anal. 2015 Mar 15;106:92-9.
• Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates. Tanase M, Zolla V, Clement CC, Borghi F, Urbanska AM, Rodriguez-Navarro JA, Roda B, Zattoni A, Reschiglian P, Cuervo AM, Santambrogio L. Nat Protoc. 2015 Jan;10(1):134-48.
• Gravitational field-flow fractionation integrated with chemiluminescence detection for a self-standing point-of-care compact device in bioanalysis. Casolari S, Roda B, Mirasoli M, Zangheri M, Patrono D, Reschiglian P, Roda A. Analyst. 2013 Jan 7;138(1):211-9.
• A novel stem cell tag-less sorting method. Roda B, Lanzoni G, Alviano F, Zattoni A, Costa R, Di Carlo A, Marchionni C, Franchina M, Ricci F, Tazzari PL, Pagliaro P, Scalinci SZ, Bonsi L, Reschiglian P, Bagnara GP. Stem Cell Rev. 2009 Dec;5(4):420-7.
• Reschiglian PR, B. Bagnara, GP. Zattoni, A., inventorMethod and device to fractionate stem cells patent PCT/EP2007/054226. 2007.
• Di Venere M, inventorDevice for the Fractionation of Objects and Fractionation Methods patent PCT/IB2015/056195. 2015.